NIH funds research on how pathogens trigger immune response

first_img Institutions involved in the Large-Scale Antibody and T Cell Epitope Discovery Program are the Scripps Research Institute in La Jolla, Calif.; Benaroya Research Institute at Virginia Mason Medical Center in Seattle; La Jolla Institute for Allergy and Immunology in San Diego; University of Oklahoma Health Sciences Center in Oklahoma City; Duke University in Durham, N.C.; Imperial College in London; Johns Hopkins University in Baltimore; University of North Carolina, Chapel Hill; Vanderbilt University in Nashville; Torrey Pines Institute for Molecular Studies in San Diego; Oregon Health and Science University in Portland; University of Copenhagen in Denmark; and the Centre for Biological Sequence Analysis at the Technical University of Denmark. The NIH statement explained that epitopes are recognized by the body’s B and T cells, which are white blood cells that detect pathogens. Each can bind only to a particular foreign molecular structure, or antigen. The specificity is determined by the receptors on the surface of each cell, the NIH said. Fourteen contracts have been approved for the Large-Scale Antibody and T Cell Epitope Discovery Program, according to the NIH, which includes the NIAID. Epitopes are the regions of infectious agents that elicit immune responses. Studying them may uncover new targets for vaccines, therapies, and diagnostic tools against potential bioterror agents, the NIAID announcement said. Such research also could reveal targets among emerging and re-emerging infectious diseases such as influenza and West Nile virus. Nov 2, 2004 (CIDRAP News) – The National Institute of Allergy and Infectious Diseases (NIAID) has awarded contracts worth more than $73 million to study the mechanisms by which certain infectious agents, including potential bioterror agents, trigger immune reactions, the National Institutes of Health (NIH) announced yesterday. The information on newly identified epitopes will be freely available to scientists on a searchable database that is being developed, the NIH said. NIAID Director Anthony S. Fauci, MD, said, “The information generated by this program will deepen our understanding of how components of the immune system defend against certain infectious agents, enabling researchers to design new and improved medical countermeasures.” The B- and T-cell specificity, as well as the diverse functions of these cells, determines the effectiveness of immune responses, the NIH said. B cells make antibodies, which bind to target antigens at their epitopes, eliminating the pathogen before infection can spread or marking it to be destroyed by other cells. T cells promote powerful antibody responses, destroy infected target cells, or control inflammation. Nearly all the contracts involve evaluating newly discovered epitopes in preclinical or clinical studies, where possible, for their capacity to prompt immune responses. This research about a wide variety of microbes will greatly expand the small-scale work that has been done for years, said Daniel Rotrosen, MD, director of NIAID’s Division of Allergy, Immunology, and Transplantation. See also: Nov 1 NIH announcementhttp://www.nih.gov/news/pr/nov2004/niaid-01.htmlast_img read more

YEAR-END REVIEW: Avian flu emerged as high-profile issue in 2005

first_imgJan 6, 2006 (CIDRAP News) – 2005 is likely to go down as the year when avian influenza, powered by a steady rise in human cases and the spread of poultry outbreaks all the way to Eastern Europe, emerged as a high-profile global health issue.When 2005 dawned, only 45 human cases of H5N1 avian flu, including 32 deaths, had been counted by the World Health Organization (WHO). All of those were in Vietnam and Thailand.A year later, the count had jumped to 142 cases with 74 deaths, including a number of cases in three previously unaffected countries: Cambodia, Indonesia, and China. (Turkey joined the list this week.)As human cases increased, outbreaks in poultry marched westward, reaching parts of Central Asia in the summer and as far west as Romania in the fall. The virus’s westward spread drew unprecedented attention around the world, fueling a flurry of planning efforts and a rush for the antiviral drug oseltamivir (Tamiflu), thought to have some protective potential against H5N1.On the research front, a clinical trial of an H5N1 vaccine being developed in the United States showed that it produced an adequate immune response, but it required a very large dose, which dimmed hopes for adequate vaccine supplies.What didn’t happen in 2005, of course, was a human pandemic. By the end of the year, the virus still had not shown an ability to spread easily from person to person. Yet scientists reported evidence of at least 15 family clusters of cases in Vietnam, suggesting that person-to-person spread may be less rare than it appears.The absence of a pandemic was the only positive news about avian flu in 2005, in the view of Michael T. Osterholm, PhD, MPH, director of the University of Minnesota Center for Infectious Disease Research and Policy, which publishes this Web site.”The only good news is that we’ve not yet seen it become a pandemic strain,” he said.The winter of 2004-05 made it clear that H5N1 flu would continue to increase and spread among domestic birds, Osterholm said. That means the virus has continuing opportunities to mutate into a humanly contagious pathogen.”The trillion-dollar question is, if this virus has virtually unlimited opportunities to accumulate mutations through its ongoing domestic bird transmission, does it have the potential to result in a competent human pathogen?” he said.If it doesn’t, the persistent outbreaks in birds have limited human consequences, Osterholm said. But he views that as highly unlikely.”I don’t know of anything in influenza research that suggests that this virus could not one day accomplish an accumulation of mutations that would allow it to become a human-to-human agent,” he said.”Some have concluded that because reassortment [combination of the H5N1 virus with a human flu virus] hasn’t occurred, it can’t accomplish human transmission. Well, the 1918 virus didn’t reassort either,” he said. He referred to recent research showing that the 1918 virus was an avian virus that adapted to humans without trading genes with a human flu virus.Human cases and poultry outbreaksA human case of avian flu reported in Cambodia last February marked the first one outside Vietnam and Thailand. Three more Cambodian cases followed within a few months, and the first symptomatic cases in Indonesia emerged in July. By the end of the year Indonesia had had 16 cases, 11 of them fatal.China reported its first two human cases since 2003 in mid-November, and five more have been reported since then. (Two human H5N1 cases in Hong Kong in February 2003—before the current poultry epizootic began—were believed to have originated in China.)Human cases continued to accumulate in Vietnam in the course of the year, rising from 28 cases with 20 deaths at the end of 2004 to 93 cases with 42 deaths a year later. Thailand escaped without any new cases until October but then had several.On the poultry front, milestones included the discovery of wild birds dying of H5N1 at Qinghai Lake wildlife refuge in north-central China in May, triggering fears that birds using the refuge would spread the virus far and wide. Those fears came true to some extent in ensuing months. In late July the virus turned up in poultry in the Novosibirsk region of Russia, and in August it was found in Kazakhstan and Mongolia.In October the virus was discovered in northwestern Turkey and in nearby eastern Romania. More recently outbreaks have been reported in eastern Turkey and southern Ukraine as well. The virus’s westward movement prompted the WHO to warn in late October that migratory birds could carry it to Africa, though that outcome hasn’t been reported so far.Research milestonesIn August the National Institutes of Health (NIH) reported that an experimental H5N1 vaccine generated an immune response in volunteers, raising hope that it could help protect people if the virus evolved into a pandemic strain. But the bad news was that the amount of antigen it took to generate a good response was a dozen times the amount in a seasonal flu vaccine. That suggested it would be virtually impossible to produce enough of the vaccine to protect most Americans, let alone the worldwide population.There was hope that the use of an adjuvant—an immune-boosting additive—could greatly reduce the necessary amount of antigen in the vaccine. But in December, Sanofi Pasteur reported that even with an adjuvant, the vaccine dose needed to generate a good immune response was still four times as much as in a seasonal flu vaccine.Osterholm commented, “Any hopes we had of taking the current vaccine supply and expanding it were seriously dashed with the NIH and Sanofi studies. Until we have a fundamental production revolution, both in terms of new vaccines and in vaccine manufacturing capacity, we’ll still have at best a very limited ability to deal with pandemics by means of vaccines.”In other research, a report published in October revealed unsettling parallels between the 1918 pandemic virus and today’s H5N1 virus. Scientists reported that the 1918 virus was an avian strain that succeeded in adapting to humans without first acquiring genes from a human flu virus. The researchers also reported that several of the mutations that differentiated the 1918 virus from purely avian viruses are also found in the H5N1 virus.Political developmentsPolicy makers in much of the world, and especially in the United States and Europe, started showing a new level of urgency during the fall. President George W. Bush, addressing the United Nations in mid-September, called for an international partnership to combat the threat.As November began, Bush called on Congress to provide $7.1 billion for pandemic preparedness, most of it for vaccines and antiviral drugs. Congress responded in December by passing a $3.8 billion measure, which included a liability shield for pharmaceutical companies.The day after Bush’s call for funding, his administration released its lengthy and long-awaited pandemic plan. The plan assumed the possibility of a pandemic sickening up to 30% of the population, a much larger epidemic than suggested in preliminary versions of the plan. The document was marked by a strong emphasis on vaccines and drugs. It was criticized as offering too little guidance and support for state and local health agencies.Federal officials followed up on the plan’s release by announcing a series of state summit meetings on pandemic preparedness, the first of which was held in Minnesota in December.Editor’s Note: Individual CIDRAP News stories on the events and research mentioned above, with links to original sources where available, can be accessed through the Avian Flu and Pandemic Flu news archives.last_img read more

Coalition declares ‘final push’ to end polio

first_img Leaders of the organizations that make up the Global Polio Eradication Initiative (GPEI)—the World Health Organization (WHO), the US Centers for Disease Control and Prevention (CDC), UNICEF, and Rotary International—announced the effort and fundraising drive in Los Angeles at Rotary’s annual convention. Members of Rotary International have been polio eradication’s volunteer shock troops since the campaign was launched in 1988 and have donated about $700 million to the effort. CDC. Update on vaccine-derived polioviruses–worldwide, January 2006-August 2007. MMWR 2007 Sep; 56(38):996-1001 [Full text] The WHO several years ago deployed a reformulated vaccine aimed at the most infectious and pathogenic form of polio, known as type 1, in hopes of shifting the balance. Uttar Pradesh remained free of type 1 for a year, but discovered an imported case from Bihar in May. Dr. Margaret Chan, the WHO director-general, said she is “committing the entire [WHO] to putting polio as our top operational priority,” but declined to offer details of how staff or funds might be shifted to carry that out. She ruled out hiring additional personnel. “We have people who can be mobilized for a short time,” she said. That approach contains a known hazard. The attenuated virus multiplies in the gut and is shed by vaccinated children, a benefit that offers potential passive immunization to other children who pick up the virus. But the vaccine virus can also mutate in the gut into a virulent type that causes polio paralysis—and, when shed, can threaten anyone not yet protected by vaccine. “The greatest danger we have now is the danger of stopping too soon,” Dr. Robert Scott, chair of The Rotary Foundation, said at a press conference. “We have to keep after this virus and finally eradicate it.” In Nigeria, polio vaccination became the subject of political and religious manipulation when clerics and local politicians seeking to upset a power-sharing agreement presented it as a Western plot against Muslim children. Vaccination essentially ceased in the country’s northern provinces from mid-2003 into 2004. But the initiative proved more costly—not only in funds, but in personnel needs and political will—than was forecast. Polio rebounded wherever attention lapsed, and it posed biological and cultural challenges that were never anticipated. “We just would like to encourage [the G8] to continue to support us to finish the job,” Chan said during the press conference. The gap between funds given and funds needed is one of many hurdles facing the long push toward eradication, which was supposed to have been achieved first in 2000 and then in 2005. Once the second deadline passed, the WHO ceased setting official targets, though its published documents project the campaign through the end of 2009. ‘Vaccine-derived’ polioThe campaign has always been dogged by a rich-poor imbalance. Industrialized countries use a more expensive injectable killed-virus vaccine, but poor countries—and the eradication campaigns operating within them—use the much less expensive, live attenuated-virus vaccine. In India’s Bihar and Uttar Pradesh states, for a complex set of reasons having to do with poor sanitation and chronic gastrointestinal diseases, polio has proved so stubborn that children remained vulnerable to it after many more doses of vaccine than the norm. The known shortfall is in addition to the more than $5 billion—$1 billion over initial projections—given since 1985, when the eradication effort began informally in the Americas as a project of the Pan American Health Organization. Representatives of many of those governments will appear at July’s G8 summit in Japan, as yesterday’s speakers acknowledged. Previous G8 summits have included commitments to continue funding eradication. Rotary fund-raising Web site International fatigue with the campaign’s complexity and cost has led some scientists, including the leader of the WHO’s successful effort to eradicate smallpox in the 1970s, to recommend abandoning eradication in pursuit of long-term control. In a news headline in May 2006, the journal Science asked: “Polio eradication: Is it time to give up?”center_img But others contend the effort must be pursued to the endgame. In a cost-benefit analysis published in The Lancet in April 2007, Kimberly Thompson and Radboud Tebbens of the Harvard School of Public Health argued that even an additional $3 billion in spending to achieve eradication would be less expensive in the long run than either the price of continued immunization for long-term control, or the human cost of paralysis if the disease escapes control. Roberts L. Polio eradication: is it time to give up? Science 2006 May 12;312(5775):832-5 [Abstract] Significant strides, but not complete successWhen the campaign began in 1988, polio paralyzed about 350,000 children per year in 125 countries worldwide. For more than a decade, the effort went well; at its lowest, in 2001, global incidence dropped to 483 new cases of the disease. The risk of “vaccine-derived polio” was graphically demonstrated last autumn when the CDC disclosed vaccine-derived polio cases in 10 countries, including a 69-person outbreak in Nigeria that paralyzed unvaccinated children. And because some rare individuals can shed virus for years, that risk has always been a troublesome wild card in plans to stop vaccinating post-eradication. “We cannot afford to not eradicate polio,” Dr. Julie Gerberding, the director of the CDC, said at the press conference. “It’s an economic imperative for us on a global basis. It’s also a moral imperative.” Arita I, Nakane M, Fenner F. Is polio eradication realistic? Science 2006 May 12;312(5775): 852-4 [Abstract] See also: Thompson KM, Tebbens RJD. Eradication versus control for poliomyelitis: an economic analysis. Lancet 2007 Apr 21;369(9570):1363-71 [Abstract] Rotary International press release Polio case counts, Global Polio Eradication Initiative Jun 18, 2008 (CIDRAP News) – The international coalition of health agencies dedicated to ending polio yesterday declared a “final push” toward the long-delayed goal of eradicating the disease. But its members coupled the announcement with a plea for millions of dollars in donations to fill shortfalls, and with an admission that the 20-year-old campaign continues to face stubborn challenges. Funding challengesBut in a sign of the challenges confronting the eradication campaign, the initiative will face a severe shortfall even if the fundraising drive succeeds. According to WHO figures, over the next 2 years the effort will need $490 million beyond what governments and private organizations have already given or committed. Yesterday’s event showcased the launch of a “$100 Million Challenge,” an effort to raise matching funds for a 3-year $100 million challenge grant given to Rotary in November 2007 by the Bill and Melinda Gates Foundation. The challenge is aimed at Rotarians, but the organization is also seeking contributions from nonmembers. Transmission has never been halted in four countries: Afghanistan and Pakistan as well as India and Nigeria. In addition, the virus spread from India and Nigeria to reinfect 27 countries where it had been eradicated, and it currently persists in nine: Angola, Benin, Chad, Niger, the Central African Republic, Ethiopia, the Democratic Republic of Congo, Sudan, and Nepal. As of Jun 10, there have been 558 new cases this year.last_img read more

Web platform for the development of cycling tourism in Croatia presented

first_imgAt the end of last year, as of December 28, a new website of the Coordination Body for the Development of Croatian Cyclotourism was registered on the domain www.cikloturizam.hr , and the development of this website was one of the tasks from the Action Plan for the Development of Cyclotourism and the Tourism Development Strategy of the Republic of Croatia until 2020.The Coordination Body for the Development of Croatian Cyclotourism deals with directing and implementing activities on the development of Croatian cycling tourism, and was established on March 16, 2016. Lidija Mišćin from the Rural Tandem Association was elected president, while Dajana Marin from the Ministry of Tourism was elected vice president. The Coordinating Body has ten member institutions / organizations, and each member has appointed its representatives in the Coordinating Body, and you can see the list of all coordinators, ie county representatives here.The Coordination Body for the Development of Croatian Cyclotourism is working on the implementation of the main tasks and priority activities from the Croatian Cyclotourism Development Action Plan, namely: infrastructure, legislation, education, cycling tourism offer, and information and marketing. Implementation activities from the Action Plan are divided into five development measures: infrastructure, legislation, education, cycling offer, information and marketing.On the new website www.cikloturizam.hr you will be able to follow the work of the Coordination Body and the activities of its members, information on EuroVelo and international cycling routes in Croatia will be available, implemented, current and future projects that contribute to the development of cycling tourism, information on events related to cycling and cycling tourism, public calls on the possibilities of financing projects intended for the development of cycling and cycling tourism infrastructure and offer, and various other topics. “With the new website we want to provide access to all interested users throughout Croatia and abroad and enable and invite them to active communication and cooperation with the Coordination Body and county representatives in it by sending specific proposals and information from the field, as well as exchanging experiences in the field of cycling in Croatian destinations”Point out the Ministry of Tourism.The establishment of the Coordination Body for the Development of Croatian Cyclotourism enabled the accession to the ECF (European Cycling Federation), which is the holder of the EuroVelo project, a network of European cycling routes connecting the countries of the European Union. By signing the Agreement with the ECF – European Cycling Federation, the Coordinating Body took over the rights and obligations regarding the management of EuroVelo routes. Given that four EuroVelo routes pass through Croatia, EV6 – Danube route, EV8 – Mediterranean route, EV9 – Baltic-Adriatic and EV13 – Iron Curtain Trail, one of the main tasks of the Coordination Body is, in addition to defining the national network of cycling routes based on existing local routes, integration into the European network of bicycle routes and work on their improvement.Photo: Kvarner.hrThe form is there, and the content and success of the whole story depends only on ourselves.Establishment of the Coordination Body for the Development of Croatian Cyclotourism as well as a web platform is certainly great news, in order for cyclotourism to develop as quickly and efficiently as possible, but again it is not the form but the content that is important. In Croatia, we are witnessing the establishment of various committees and working groups, while their efficiency is no or very poor. Also, the most important thing is the synergy and open dialogue of everyone from institutions, associations to people who are actively involved in the development of cycling tourism, who have the most experience and know the situation on the ground, both in Croatia and in Europe. Efficiency and speed of decision-making is a big problem in Croatia, we are too slow to accept new trends. While we only talk for years, the competition does not sleep, but makes much faster decisions, and thus moves us away by setting more and more standards. Also, in addition to the above, we lack more profession and people from the private sector who live cycling tourism every day, and the State is there to implement all activities as an extended arm so that cycling tourism can develop well.The success of the Coordination Body for the Development of Croatian Cyclotourism will be measured precisely by the efficiency and speed of decision-making. I sincerely hope that in a year of work of the Coordination Body for the development of Croatian cycling tourism we will have concrete positive changes because time flies fast, and time is our biggest “enemy” in today’s fast-growing tourist market.Side dish: Action plan for the development of Croatian cycling tourismRelated news:MARTIN ČOTAR: “THE POTENTIAL OF CYCLOTURISM IS GREAT, WE JUST NEED TO PACK AND SELL IT WELL” KREŠIMIR HERCEG, BICYCADEMY: THE POTENTIAL OF CYCLOTURISM IN SLAVONIA IS HUGElast_img read more

UHPA Day program published in Vinkovci

first_imgUHPA Days is an annual meeting organized by UHPA, the largest national professional association of travel agencies, bringing together more than 150 participants, travel agencies – UHPA members, representatives of the Ministry of Tourism, Croatian Chamber of Commerce, Croatian National Tourist Board, tourism professional associations and other Croatian stakeholders. tourism sector. Thus, 2019 will certainly be a great positive turning point for Slavonia, since the UHPA Days and the Days of Croatian Tourism (Vinkovci, Osijek) will be held in Slavonia. UHPA Days 2019 will be held from 21. to 23.03.2019. years in the oldest European city – Vinkovci. The three – day program envisages interesting presentations, expert lectures and social events primarily intended for UHPA members, but also for other stakeholders in the Croatian tourism sector. center_img Whole preliminary program UHPA Day 2019 read HERE This is a great opportunity for the whole of Slavonia to present its tourist offer to travel agencies and meet agents and representatives of travel agencies directly on the spot.last_img read more

Open public hearings: Rulebook on types of nautical tourism vessels and Rulebook on classification and categorization of agreements. obj. in camps

first_imgPublic debate – eConsulting 1. Ordinance on the types of nautical tourism vessels  The deadline for giving an opinion is 24.5. , and so far there is only one comment. Get involved, now is the time for constructive and reasoned suggestions and opinions. When the new Regulations are adopted, it will be too late to “smart up” and raise the storm in the media and social networks. center_img 2. Ordinance on amendments to the Ordinance on classification and categorization of catering facilities from the group of camps The Ministry of Tourism published on the e-consultation portal Ordinance on the types of nautical tourism vessels i Ordinance on amendments to the Ordinance on the classification and categorization of catering facilities from the group of camps . last_img read more

The Tourist Board of the city of Dubrovnik presented its offer at the tourist fair in Japan

first_imgThe Tourism Expo Japan was held from October 24 to 27 in the Japanese city of Osaka. The Tourism Expo Japan was attended by exhibitors from about 140 countries around the world and was declared one of the most attractive and productive tourism events in the world. From the beginning of 2019 to October 22 in Dubrovnik, Japanese tourists realized 35.439 arrivals and 71.749 overnight stays, which is 6 percent more in arrivals and 6 percent more in overnight stays. At this fair, the Dubrovnik Tourist Board performed for the first time at a joint stand with the Dubrovnik-Neretva County Tourist Board and together with the tourist boards of the City of Zagreb, Šibenik-Knin County and Lika-Senj County. About 1.300 exhibitors from 140 countries exhibited at the Tourism Expo Japan, and it was visited by about 200.000 visitors.center_img The first two days were intended exclusively for tourism professionals, while the other two days the doors of the fair were open to all visitors. In 2018, this fair was held in Tokyo, and it was visited by 207.352 visitors, of which over 50.000 are professionals in tourism, reports Dubrovnik Herald. Source / photo: Dubrovnik Tourist Board; Dubrovački vjesnik; Tourism Expo Japanlast_img read more

Voice of Entrepreneurs Association: The State Inspectorate continues its repression

first_imgAccording to the information that the Association receives today from the field from the owners of sealed restaurants, they say just the opposite. ”Despite public appearances full of cooperation, the state inspectorate seems to be fulfilling the worst fears of Croatian entrepreneurs – by retaliating it is retaliating for trying to continue doing business, and continuing to act. ” allegations from UGP. UGP research: Is the inspectorate doing a good job? UGP recently conducted a survey among its members where they surveyed the opinion of entrepreneurs on the topic of the work of the inspectorate. To the question: Are Andrija Mikulić and the inspectorate doing a good job? – Almost 99% of respondents believe that the inspectorate and the chief state inspector are not doing well. About 16% of them think that they are closing down companies unnecessarily, and 83% think that apart from not doing their job well and only “racketeers”, Andrija Mikulić should also be fired. “What you asked for, you got “- This is the response of the State Inspectorate to sealed restaurants, whose employees cannot enter the sealed facility to comply with the requirements of the CNIPH,” said in a statement from the Association Voice of Entrepreneurs.  “What you asked for, you got” was a loud version, after which the official of the State Inspectorate of Peaceful Conscience and satisfied with what was done turned around and left the facility – closed, they point out from the UGP and add: “The owner asked us this morning for advice and help. With the quick intervention of the Voice of Entrepreneurs Association and contacting the Chief Inspector in Rijeka, we managed to solve this problem and at least calm the situation down for now, and the said caterer will still be able to prepare his facility for opening ”  On Sunday, the Voice of Entrepreneurs Association (UGP) pointed out the inconsistent conduct of the inspectorate in the supervision of catering facilities. They insisted on prescribing clear working conditions, which did not exist until now, so that everyone knew what to do. The same evening on HRT, and on Monday 20.4. The Director of the State Inspectorate, Mr. Andrija Mikulić, confirmed that the closed restaurants will be allowed to operate as soon as they meet the conditions and announced the suspension of the proceedings. This morning, when the sealing of the proceedings was to start, the competent inspector in Rijeka left the facilities – sealed, because in the meantime they did not meet the new conditions of the CNIPH, which you cannot meet because entrepreneurs do not have access to their business premises.  Photo: Pixabay.comlast_img read more

20 percent of tourists stay in Croatia compared to last year

first_imgDue to the further development of the favorable epidemiological situation, the Civil Protection Headquarters of the Republic of Croatia continued to mitigate the measures and issued three Decisions: For the beginning of the first extended weekend after the relaxation of epidemiological measures via the Enter Croatia system, 112.023 reports have been received so far for 235.035 people who, in addition to fulfilling the prescribed conditions, have already entered or announced entry into the Republic of Croatia. According to the records, 13,00 persons entered the Republic of Croatia today by 24 pm, ie in the last 104.782 hours, of which 55.319 were citizens of the Republic of Croatia and 49.463 foreign citizens, which is 30% more than the previous day. The total (foreign and domestic) number of arrivals in the first five months was 732.666 (down 80,5%), while 2.828.283 overnight stays were recorded (down 75,0%). During the first five months, the majority of tourist traffic was registered in commercial accommodation facilities (72%), while non-commercial accommodation facilities participated in the total traffic with a share of 27%. The day before, on June 10, a total of 80.808 passengers entered, of which 44.158 were citizens of the Republic of Croatia and 36.650 foreign citizens.Out of the total number of foreign citizens, the most arrivals are citizens of Slovenia 16.668, followed by Austria 9.488 and Germany with a total number of 8.239. The most visited counties are: Istria, Primorje-Gorski Kotar and Zadar counties, while the destinations with the largest number of tourists are Rovinj, Vir, Mali Lošinj, Medulin, Krk. Registration via the Enter Croatia page is not mandatory, but it is recommended that all tourists take the opportunity to sign up at Enter Croatia to avoid longer waits at the border and to keep border controls as short as possible. The National Civil Protection Headquarters made three decisions today These decisions extended the existing regime of crossing the border crossings of the Republic of Croatia until 30 June 2020, enabled the establishment of rail and road international public transport in compliance with the recommendations and instructions of the Croatian Institute of Public Health and abolished the ban on trade on holidays and non-working days. days, which means that it is possible to establish working hours as before the declared epidemic of COVID-19, but still with the mandatory application of anti-epidemic measures and compliance with all recommendations and instructions of the Croatian Institute of Public Health. In the first five months the number of arrivals decreased by 86% Decision amending the Decision on temporary prohibition of crossing the border crossings of the Republic of CroatiaDecision on the manner of organization of public transport during the declared epidemic of COVID-19 diseaseDecision amending the Decision on working hours and manner of work in the activity of trade during the declared epidemic of the disease COVID-19 According to the eVisitor system, in the first five months of 2020, the number of foreign tourist arrivals was 417.284 (down 86,2%), while 315.382 domestic tourist arrivals were recorded (down 56,9%). In the same period, 1.498.863 overnight stays of foreign tourists were realized (decrease of 84,2%) as well as 1.329.420 overnight stays of domestic tourists (decrease of 28,0%). Until yesterday, there were 115 thousand tourists in Croatia, or about 20 percent of tourists compared to the same time last year. last_img read more